Introduction. Caffeine (CAF) is widely consumed psychoactive substance and one of the most used supplements. Due to the fact that strength and power training has become an essential component of conditioning programs in most of the competitive sports, the need for more specific analysis of CAF in terms of resistance training has been established. Furthermore, most of the research focused on the acute effects of CAF supplementation on muscle performance utilized the bench press (BP) exercise. Taking into consideration the popularity of the BP exercise, the main purpose of this review is to evaluate the current state of knowledge on the impact of CAF supplementation on the BP performance and to point out practical guidelines. Material and Methods. PubMed, Medline and GoogleScholar databases were searched from 2006 to 2020 for studies evaluating the effects of CAF on: (1) maximal muscle strength; (2) power output; and (3) strength-endurance performance as assessed in the BP exercise. Twenty-three articles met the inclusion criteria and were consequently included in the review. Results. In general, CAF in doses of 3 to 6 mg/kg has been found to be a safe ergogenic aid during the BP exercise in terms of improving maximal strength and power output, however the impact of CAF intake on strength-endurance is less clear. Additionally, doses of 9 mg/kg and 11 mg/kg might be ergogenic in the improvement of maximal strength and power output, however higher frequency of side effects observed has to be considered in supplementation strategy. Conclusions. The performed review showed that acute CAF intake can be an effective strategy to improve resistance training outcomes for maximal strength and power output tests during the BP exercise. However, extrapolation of these guidelines to long-term benefits of CAF influence on the BP exercise remains limited due to lack of evidence in this area.